How a tryptophan-rich allosteric communication network helps activate a major drug target receptor

A multinational research team led by researchers at Institute of Science Tokyo, RIKEN, and the University of Toronto has ...

INDIGO Biosciences Launches CHRM1 (Cholinergic Receptor, Muscarinic 1) Reporter Assays for Cognitive Drug Discovery

New Assay Expands INDIGO’s GPCR Portfolio and Supports Development of Next-Generation CNS-Related Therapeutics STATE ...
Healio

Allosteric modulator nonsuperior to placebo in Parkinson’s disease

Please provide your email address to receive an email when new articles are posted on . Change from baseline in gait variability did not differ between groups, regardless of cognitive load. Treatment ...
sciencex

Allosteric modulation of G-protein-coupled receptors as a novel therapeutic strategy in neuropathic pain

A publication from Acta Pharmaceutica Sinica B discusses allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain. Neuropathic pain is a debilitating ...
Healio

Neurosterix launches with $63 million to advance allosteric modulator therapeutics

Please provide your email address to receive an email when new articles are posted on . A Swiss biopharmaceutical company announced its launch with $63 million in Series A financing for research and ...
BioWorld

Sage Therapeutics divulges new GluN2A negative allosteric modulators

Sage Therapeutics Inc. has synthesized sterol derivatives acting as glutamate receptor ionotropic, NMDA 2A (GRIN2A; GluN2A) negative allosteric modulators reported to be useful for the treatment of ...

Unlocking the hidden pocket on a billion‑dollar drug target

For years, a protein inside our cells has quietly powered billions of dollars' worth of cancer drugs. Now a team of ...