Researchers have identified a novel molecule in the brain that, after stroke, blocks the formation of new connections between neurons. As a result, it limits the brain’s recovery. In a mouse model, ...

Stroke is the leading cause of adult disability because of the brain's limited capacity for repair. Stroke induces axonal sprouting and the formation of new connections in peri-infarct cortex that ...

Stroke is an age-related disease. Recovery after stroke is associated with axonal sprouting in cortex adjacent to the infarct. The molecular program that induces a mature cortical neuron to sprout a ...

A stroke wreaks havoc in the brain, destroying its cells and the connections between them. Depending on its severity and location, a stroke can impact someone's life forever, affecting motor activity, ...

Researchers report that the deletion of the PTEN gene would enhance compensatory sprouting of uninjured CST axons. Furthermore, the deletion up-regulated the activity of another gene, the mammalian ...

Agnes (Yu) Luo, PhD. [University of Cincinnati] After a stroke, extracellular matrix (ECM) molecules known as chondroitin sulfate proteoglycans (CSPGs) become barriers to axonal plasticity and ...

Axonal regrowth is a crucial process for forming a compensatory neuronal network after spinal cord injury (SCI), but this is very limited in the adult mammalian central nervous system.