Nature

The complement system as a potential therapeutic target in rheumatic disease

The complement system is activated in many rheumatic diseases, as evident from deposition of activation fragments in affected tissue, decreased residual complement function and increased levels of ...
Nature

The complement system: a gateway to gene–environment interactions in schizophrenia pathogenesis

What can be done in the face of the analytic challenges? One practical solution is a step-wise progression, starting with well-accepted genetic risk factors that are paired with established or ...
JSTOR Daily

Neutrophils from Patients with Advanced Human Immunodeficiency Virus Infection Have Impaired Complement Receptor Function and Preserved Fcγ Receptor Function

Interleukin (IL)-8 production by human polymorphonuclear leukocytes (PMNL) to Cryptococcus neoformans is related to complement activation. Generation of the bioactive fragments C3a and C5a is ...
The New England Journal of Medicine

Immunodeficiency and Genetic Defects of Pattern-Recognition Receptors

The susceptibility of adopted children to infection correlates more with the susceptibility of their biologic parents than with that of their adoptive parents. 1 This suggests that genetic factors can ...