T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on exquisitely timed molecular signals. Now researchers have captured one of the ...

Your brain’s “stop eating” signal may come from an unexpected source. Researchers found that astrocytes—once thought to just support neurons—actually play a key role in controlling appetite. After a ...

Cornell researchers have uncovered a built-in molecular "gate" that controls the production of the molecule nitric oxide, a crucial signaling molecule throughout biology that in humans helps regulate ...

For decades, scientists understood inducible nitric oxide synthase, or iNOS, as a one-trick enzyme. Its job was to churn out nitric oxide, a reactive molecule the immune system uses to kill bacteria ...

Mitochondrial defects are associated with the development of diseases such as type 2 diabetes (T2D). Studies in mice and in human tissues, by researchers at the University of Michigan, have now found ...

A new study shows how an anticancer drug triggers an 'outside in' signal that gets it sucked into a cancer cell. The work reveals a new signaling mechanism that could be exploited for delivering other ...

Non-immune cells play a crucial and often underappreciated role in host defense against invading pathogens. Beyond serving as passive physical barriers, ...

Cancer cells that accumulate extra copies of their entire chromosome set can start behaving like immune cells, swallowing their neighbors and migrating through tissue to seed tumors in distant organs.