Regulatory mechanisms governing the sequence from progenitor cell proliferation to neuronal migration during corticogenesis are poorly understood 1,2,3,4,5,6,7,8,9,10. Here we report that ...

Hennah, P. & Porteous, D. The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes. PLoS One 4, e4906 (2009). The alternative text for this image may ...

A protein called disrupted-in-schizophrenia 1, encoded by the DISC1 gene, has been established as a genetic risk factor for a wide array of psychiatric disorders, including schizophrenia, bipolar ...

Adapted from a story that originally appeared on the Schizophrenia Research Forum. A new study reveals an intriguing link between two top suspects in schizophrenia, neuregulin-1 (NRG1) and disrupted ...

How much was previously known about the 'disrupted in schizophrenia-1' DISC-1 gene? The DISC-1 gene has been studied intensively over the years because people with mutations in DISC1 have a high ...

Johns Hopkins researchers report the discovery of a molecular switch that regulates the behavior of a protein that, when altered, is already known to increase human susceptibility to schizophrenia and ...

Koki Ito, a postdoctoral researcher at Johns Hopkins University, inserts DNA containing a mutated DISC1 gene into a mouse fetus. Schizophrenia and other serious mental illnesses typically manifest ...

Scientists have long eyed mutations in a gene known as DISC1 as a possible contributor to schizophrenia and mood disorders, including depression and bipolar disorder. Now, new research suggests that ...

Researchers have identified a protein that regulates a gene associated with schizophrenia. The study’s findings have significant implications for schizophrenia treatment. Researchers from the ...

Schizophrenia affects around 1% of the global population and can cause paranoia, hallucinations and a breakdown in patients’ thought processes, with a huge impact on their ability to carry out ...

DISC1 (disrupted-in-schizophrenia 1), originally identified in a large Scottish family suffering from multiple psychiatric disorders due to a chromosomal translocation-induced disruption, has been ...