Cancer’s strongest gene switches push DNA into damaging overdrive, creating repeated breaks and repairs that may fuel tumor ...

In a new UCLA-led study, investigators shed light on the intricate processes underlying cancer evolution and define the optimal algorithms to analyze the genetic makeup of tumors. Understanding the ...

Cancer does not develop overnight. It can take decades for cancer-promoting changes in the genome to eventually lead to the formation of a malignant tumor. Researchers at the German Cancer Research ...

Researchers at the Josep Carreras Leukaemia Research Institute propose a new view of cancer based on spatial hallmark ecosystems and its evolution during cancer progression. This conceptual framework ...

The authors created detailed 3D renderings of tumors from more than 2,000 individuals, with breast, colon, pancreatic, kidney and uterine cancers, among others. From these detailed atlases, the ...

EVOFLUx uses DNA methylation fluctuations as molecular barcodes to trace tumor evolution, offering insights into growth, treatment resistance, and prognosis. The method requires only bulk methylation ...

Researchers published a new study, “Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution,” in Cell that they say solves the mystery of what drives the genomic ...

Serial circulating tumor DNA analysis can demonstrate rapid clonal dynamics that evolve during response and resistance to both standard chemotherapy and targeted therapy of BRAF-mutant colon cancer ...