The FHIT gene, located at human chromosome 3p14.2, is frequently deleted in a number of human cancers, and interstitial deletions at this site were recently described in a significant proportion (41%) ...

FHIT gene structure and protein expression have been examined in detail in many types of cancers (for a review, see Huebner and Croce, 2003). Fhit expression is reduced or absent in the majority of ...

In other cancers, Fhit inactivation seems to be a later event, possibly associated with progression to more aggressive neoplasias. Thus, detection of Fhit expression by immunohistochemistry in ...

Edited by: Eugene Russo Photo: Robert Neroni Photo: Michael Price PERFECT FHIT: Kay Huebner and Carlo Croce of the Kimmel Cancer Center discovered a correlation between the deletion of the FHIT gene ...

Common fragile sites are regions that show elevated susceptibility to DNA damage, leading to alterations that can contribute to cancer development. FRA3B, located at chromosome region 3p14.2, is the ...