Inflammatory bowel disease (IBD) and other intestinal disorders affect millions of people worldwide, often causing lasting ...

All animals possess some capacity for repairing and replacing the lining of their intestines, a process called intestinal regeneration. In mammals, including humans, this constant but relatively minor ...

Research from an international team finds that the human gut is a site of rapid change, with recent and important deviations from other mammals, including our closest living relative, the chimpanzee.

Intestinal tuft cells divide to make new cells when immunological cues trigger them. Additionally, in contrast to progenitor- and stem cells, tuft cells can survive severe injury such as irradiation ...

Tuft cells are present throughout the intestinal tract as well as in many organs. Studies in mice have shown that when tuft cells sense the presence of pathogens, they signal to immune cells and to ...

For the roughly 3 million Americans living with inflammatory bowel disease, the current treatment options tell a frustrating story. Anti-TNF biologics such as infliximab and adalimumab, the backbone ...

In a breakthrough for the advanced study of gut health, scientists have developed a 3D microscopic version of the human intestines condensed into a small chip about half the size of a five-cent coin.

While in vivo animal models are commonly employed for pharmacokinetic studies, they are often expensive, low in throughpu,t and typically fail to accurately replicate key characteristics of the human ...

Organ-Chips as a Platform for Studying Effects of Space on Human Enteric Physiology (Gut on Chip) examines the effect of microgravity and other space-related stress factors on biotechnology company ...