Our proteome is much bigger than our genome because one gene produces several variants of proteins called protein isoforms, whose disbalance is implicated in many diseases. A new bioengineered ...

Researchers have identified a new way to make opioids safer, increasing the pain-relieving properties of opioids while decreasing unwanted side effects through the spinal inhibition of a Heat shock ...

A team led by researchers at UCLA and the University of Pennsylvania has produced a first-of-its kind catalog of gene-isoform variation in the developing human brain. This novel dataset provides ...

One of the biggest challenges in cancer treatment is that certain cancers reappear after chemotherapy-and an aggressive type of blood cancer called acute myeloid leukemia (AML) is notorious for this.

Single-cell RNA sequencing (scRNA-seq) emerged to characterize gene expression differences between individual cells derived from a complex tissue, allowing a higher resolution look at mRNA expression ...

Reveal Hidden Biology by Combining Long Fragment Target Capture with SMRT Sequencing While the power of whole human genome sequencing to fuel discovery is unparalleled, there are many research ...

Sequential use of antibody-drug conjugate after antibody-drug conjugate for patients with metastatic breast cancer: ADC after ADC (A3) study. This is an ASCO Meeting Abstract from the 2023 ASCO Annual ...

Researchers developed MIL33B, a high-affinity antibody that selectively targets the tumor-associated 4Ig-B7-H3 isoform while sparing the soluble decoy form. Radioligand therapy with 90Y-MIL33B ...

OXFORD, England--(BUSINESS WIRE)--Oxford Nanopore Technologies plc (Oxford Nanopore) today announces a collaboration with 10x Genomics, to enable a streamlined workflow for sequencing full-length ...