Precise synaptogenesis is crucial to brain development, and depends on the ability of specific partner cells to locate and communicate with one another. Dynamic properties of axonal filopodia during ...

Adipose-derived stem cells-transdifferentiated motoneurons after transplantation can integrate in the host cord. However, cell survival has been restricted by a lack of ideal environment for nerve ...

During central nervous system development, about 50% of the neurons produced subsequently die by programmed cell death. Classically, it is thought that supernumerary neurons die because they fail to ...

Boosting communication between the spinal nerves and the muscles using the spinal cord stimulation reverses spinal muscle atrophy (SMA) progression and could be applied to other motoneuron diseases, ...

University of Pittsburgh School of Medicine researchers carrying out a small pilot clinical trial demonstrating that a drug-free, minimally invasive intervention targets the root cause of progressive ...

PITTSBURGH, Feb. 5, 2025 – A new drug-free, minimally invasive intervention targets the root cause of progressive loss of neural function in spinal muscle atrophy (SMA), an inherited neuromuscular ...