Researchers from Fujita Health University, Japan, uncover specific gene mutations and mechanisms that may contribute to the development of colorectal tumors that lack mutations in key oncogene drivers ...

Assessment of PARP1 mRNA expression as prognostic of aggressive pathology and adverse outcomes, and as predictor of response to PARP inhibition in castration-sensitive prostate cancer. Association of ...

Comparing the Diagnostic Yield of Germline Exome Versus Panel Sequencing in the Diverse Population of the Texas KidsCanSeq Pediatric Cancer Study We obtained 79 samples of metastatic peritoneal tumor ...

Missense mutations influence protein abundance in prostate cancer. Using a SILAC-based quantitative proteomics approach, we identified significant proteomic differences between healthy and tumor ...

The metastatic breast cancer (mBC) landscape is evolving rapidly due to the increasing prevalence of ESR1 mutations, a key driver for hormone receptor-positive (HR+) patients. ESR1 mutations, ...

Targeted resequencing of DNA allows researchers to focus on genes of interest for cost-effective analysis of genetic variations. Typically, to analyze single nucleotide mutations and copy number ...

Scientists discovered that the first 100 base pairs of human genes are unusually prone to mutations, especially during the earliest stages of embryonic development. These mosaic mutations often go ...

Are you a super-sleeper? Rare mutation means some people thrive on just 4 hours a night - People with rare mutation appear to ...

More than two years after H5N1 bird flu was first detected in U.S. dairy cattle, the virus has proven remarkably good at infecting cows and flooding raw milk with viral material. What it has not done, ...