Bioavailability of the hedgehog pathway inhibitor GDC-0449 in a phase I pharmacokinetic (PK) study in healthy female subjects. Background: Serdemetan is a compound that can cause replicative stress ...
A recent study published in Scientific Reports developed pharmacokinetic (PK) pharmacodynamic (PD) models of maintenance therapy for acute lymphoblastic leukemia (ALL). Study: ...
Phase I study of sorafenib (S) with bevacizumab (B) and paclitaxel (P) in patients (pts) with refractory solid tumors. Phase I evaluation of telatinib, a vascular endothelial growth factor receptor ...
One PK/PD model helps researchers predict the disposition of a drug from the body and its penetration to the target organs. The model incorporates data from animal tests on the new drug and on a ...
In this free webinar, gain insight into how model-informed drug development uses early PK/PD data, extrapolation and simulation to enable earlier, regulator-ready pediatric dose selection with fewer ...
PRINCETON, N.J.--(BUSINESS WIRE)--Certara®, the global leader in model-informed drug development, regulatory science, market access and real-world evidence services, today announced the launch of ...
The US Food and Drug Administration (FDA) on Thursday finalized guidance on population pharmacokinetics, more than two decades after first issuing draft guidance on the topic. “Population PK analyses ...
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