News Medical

A novel pharmacology modeling approach to monitor acute lymphoblastic leukemia treatment

A recent study published in Scientific Reports developed pharmacokinetic (PK) pharmacodynamic (PD) models of maintenance therapy for acute lymphoblastic leukemia (ALL). Study: ...
ascopubs.org

Pharmacokinetic–pharmacodynamic (PK-PD) modeling and simulation of serdemetan-induced QTc effects in a first-in-human study.

Bioavailability of the hedgehog pathway inhibitor GDC-0449 in a phase I pharmacokinetic (PK) study in healthy female subjects. Background: Serdemetan is a compound that can cause replicative stress ...
Yahoo Finance

Transforming Pediatric Rare Disease Trials Through Modeling and Simulation, and Site Networks, Upcoming Webinar Hosted by Xtalks

In this free webinar, gain insight into how model-informed drug development uses early PK/PD data, extrapolation and simulation to enable earlier, regulator-ready pediatric dose selection with fewer ...
ascopubs.org

Utilizing mechanistic PK/PD modeling to simultaneously examine free CCL2, total CCL2, and CNTO 888 serum concentration time data.

Final report of phase I clinical, pharmacokinetic (PK), pharmacodynamic (PD) study of PF-00562271 targeting focal adhesion kinase (FAK) in patients (pts) with solid tumors. A phase I dose-escalation ...
Business Wire

Certara Launches Version 8.2 of Its Industry-Leading Phoenix PK/PD Modeling and Simulation Software for Drug Development

PRINCETON, NJ--(BUSINESS WIRE)--Certara®, the global model-informed drug development and decision support leader, today announced the launch of Phoenix® 8.2, the ...