In eukaryotes, 26S proteasomes mediate a major fraction of intracellular protein degradation 1. This ~2.5-MDa protease complex consists of a 20S proteasome core capped on one or both ends by the 19S ...
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T-helper (Th) lineages have been generated in vitro by activating CD4 cells with anti-CD3/CD28 antibodies during polarization. Physiologically, however, the generation of Th lineages is by activation ...
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