By understanding how milligram to kilogram peptide production is achieved safely, drug developers can better navigate the ...

Nature makes amide bonds—the key linkages that string together amino acids in a polypeptide—like a knitting whiz. The ribosome in Escherichia coli bacteria, for example, can make eight amide bonds in ...

Chemical synthesis and peptide ligation techniques have revolutionised the field of protein engineering by enabling the precise construction of peptides and proteins with tailored modifications. These ...

Cyclic peptides offer enhanced stability and bioavailability, but precise cyclization strategies and specialized synthetic techniques are required to maintain their biological activity. A recent ...

The PurePep ® Sonata ® is a mid-pilot scale peptide synthesizer that has been designed to provide more reliable and robust workflows. PurePep Sonata introduces real-time flow technology to streamline ...

Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL) have addressed a long-standing challenge in the pharmaceutical industry, with the development of a two-step, one-pot method for ...

A team at ETH Zurich developed a new peptide-based organocatalyst that handles macrocycle formation from start to finish. Macrocyclic compounds are ubiquitous both in nature and in the chemical ...

The breakthrough could simplify the production of complex proteins used in cancer immunotherapy and other advanced medicines ...

For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat ...