The alternative text for this image may have been generated using AI. Figure 2: Tb 3+ reports a STIM1-dependent conformational change in the ORAI1 channel. The alternative text for this image may have ...

A recent study unveils how stromal interaction molecule 1 (STIM1), a protein involved in calcium signaling, plays a pivotal role in the resistance of liver cancer to sorafenib, a key treatment for ...

Triggered by decreases in ER Ca2+ level, conformational changes of the endoplasmic reticulum (ER) luminal domain in STIM1 would switch on its cytoplasmic domain (CT) to engage and gate ORAI channels ...

Two recent studies report how a calcium-sensing protein called STIM1 signals that it's time to initiate calcium retrieval and then relays that message to its partner, the calcium channel ORAI. All ...

This is a preview. Log in through your library . Abstract Store-operated Ca2+ entry (SOCE), mediated by the endoplasmic reticulum (ER) Ca2+ sensor stromal interaction molecule 1 (STIM1) and the plasma ...

This is a protein chemist’s depiction of the calcium-sensing region in two engineered STIM1 protein variants. The sites that were altered are highlighted in each case as red spheres. The behavior of ...

Researchers at Delhi’s CSIR-Institute of Genomics and Integrative Biology (IGIB) have for the first time identified a calcium sensor protein (STIM1) that independently regulates both skin cancer and ...

Mindfulness-Based Cognitive Therapy in Advanced Prostate Cancer: A Randomized Controlled Trial IM was prospectively discontinued in 100 patients with CML with UMRD sustained for at least 2 years.

John Chatham, Ph.D., Professor, Molecular & Cellular Pathology, was recently awarded an R01 from the National Heart, Lung, and Blood Institute titled, "STIM1 and its Role in Regulating Cardiac ...