Neurodegenerative diseases are commonly adult-onset conditions characterized by degeneration of specific neuronal populations. Familial forms are caused by mutations in single genes, but most patients ...

A team at UT Southwestern Medical Center has identified a structural trick that lets viruses translate their genetic code inside human cells, even when that code is riddled with “bad” codons the host ...

Researchers are redesigning lipid nanoparticles to do more than shuttle mRNA into cells, with preclinical studies suggesting ...

Proteolysis-targeting chimeras (PROTACs) are an increasingly established modality to induce protein degradation by bridging the protein target to proteolytic machinery. Ribonuclease-targeting chimeras ...

The field of RNA-targeted therapeutics is rapidly evolving, offering groundbreaking opportunities for the treatment of a wide array of diseases ...

A potential drug targets RNA that cause C9 ALS and frontotemporal dementia. One of the most commonly inherited forms of ALS and frontotemporal dementia is referred to as C9 ALS/FTD, so named for the ...

Early in the coronavirus disease 2019 (COVID-19) pandemic, it was clear that quick and accurate diagnostic techniques were required to deal with emerging infections and offset the negative impacts of ...

For a long time, extracellular vesicles (EVs) were often thought of as garbage bags containing a myriad of materials that cells don’t need. But scientists have since learned that EVs are instrumental ...

In 2018, the RNA Society endorsed Aug. 1 as annual World RNA Day, and depending on when you’re reading this article, the anniversary of that day is either upon you now or has likely passed you by ...

Researchers have made a significant advance in understanding how genes are controlled in living organisms. The new study focuses on critical snippets of RNA in the tiny, transparent roundworm ...