Sir2, an enzyme belonging to sirtuins, has been effectively involved in the deacetylation of proteins. A tandem allosteric effect of reactant and product is responsible for the efficient deacetylation ...

You have full access to this article via your institution. But what does this mean? The authors suggest that, in S. cerevisiae, Sir2 inhibits the initiation of DNA replication at a step early in ...

Low-calorie diets extend lifespan in almost every model tested, but scientists can't yet agree on what controls this phenomenon. The histone deacetylase Sir2 provides a seductive link between gene ...

A protein called Sir2 may facilitate C. albicans' transition from ovoid yeast to thread-like hypha. C. albicans cells that were missing the Sir2 gene were less likely to form true hyphae in lab ...

Sir2, an enzyme belonging to sirtuins, has been shown to be involved in the deacetylation of proteins. Researchers from the Institute of Science Tokyo reveal that a tandem allosteric effect of ...

A counterintuitive experiment has resulted in one of the longest recorded life-span extensions in any organism and opened a new door for anti-aging research in humans. Scientists have known for ...

The family of histone deacetylase proteins known as sirtuins have been heralded as keys to longevity, based largely on studies in yeast, flies, and worms. New data now call these findings into ...

Our cells are usually frantically working to sustain life. Part of this work includes dividing, a process that creates more cells to support our growth when we are children or to replace old, worn-out ...

From The Bedalov Lab, Human Biology and Translational Science and Therapeutics Divisions Thus, the team began this current study with a scavenger hunt for a nucleosome-modifying enzyme which could ...

BUFFALO, N.Y. — You might call Candida albicans a shape-shifter: As this fungus grows, it can multiply as single, oval-shaped cells called yeast or propagate in an elongated form called hypha, ...