Certain cells in the brain create a nurturing environment, enhancing the health and resilience of their neighbors, while others promote stress and damage. Using spatial transcriptomics and AI, ...

This figure shows how the STAIG framework can successfully identify spatial domains by integrating image processing and contrastive learning to analyze spatial transcriptomics data effectively.

In the brain, location is everything. And the throngs of cells that live there are nothing without the billions of distinct connections between them. Although scientists can use single-cell ...

Integrated mass spectrometry imaging and spatial transcriptomics reveal that amyloid-β plaques differ in composition and local tissue responses, offering insight into Alzheimer’s disease heterogeneity ...

Biological tissues are made up of different cell types arranged in specific patterns, which are essential to their proper functioning. Understanding these spatial arrangements is important when ...

Perhaps our most defining characteristic as a species, the six-layered human cortex, hosts billions of neural connections that bestow Homo sapiens with higher-order thinking. But how does this ...

Fei Chen and Chenlei Hu at the Broad Institute of MIT and Harvard have developed a new imaging-free spatial transcriptomics technology that tracks the diffusion of DNA barcodes between beads in an ...

Breakthrough research details how distinct tissue niches and cell communication contribute to chronic active lesions in MS. Study: Cell type mapping reveals tissue niches and interactions in ...