This study aimed to critically appraise the current level of economic evidence available for thiopurine S-methyltransferase (TPMT) testing of thiopurine drugs, such as azathioprine. Six economic ...
Mayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs. TPMT∗8 is relatively common in individuals of African or ...
Interest in thiopurine S-methyltransferase (TPMT) emerged initially because of the important role this enzyme plays in metabolic transformation of the widely used anticancer and anti-inflammatory ...
ROCKVILLE, Md. – Aug. 25, 2022 – The Association for Molecular Pathology (AMP), the premier global molecular diagnostic professional society, today published consensus recommendations to aid in the ...
Background. A 50-year-old man who had received a simultaneous pancreas and kidney transplant 9 years earlier developed pancytopenia 3 weeks after starting azathioprine therapy to treat worsening ...
The promise of pharmacogenetics, the study of the role of inheritance in the individual variation in drug response, lies in its potential to identify the right drug and dose for each patient. Even ...
To optimize drug concentration and improve outcomes, therapeutic drug monitoring is used to check the trough concentration and evaluate for the presence of anti-drug antibodies. The American ...
Personalized Medicine. 2009;6(1):103-113. The six economic evaluations were all retrospective modeling studies that synthesized existing clinical and cost data supplemented by expert opinion where ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results