New atlas that charts tumor cell diversity could guide personalized therapy for head and neck cancer

Head and neck squamous cell carcinomas (HNSCC) are the seventh-most prevalent form of cancer and are associated with human ...

Study maps complex interplay between cells, metabolism, and immunity in breast cancer lymph node metastasis

A recent integrative analysis of single-cell sequencing and single-cell spatial mapping of lymph node metastasis in breast cancer reveals novel mechanisms of the metabolic-immune interaction that ...
EurekAlert!

MIT invents human brain model with six major cell types to enable personalized disease research, drug discovery

A new 3D human brain tissue platform developed by MIT researchers is the first to integrate all major brain cell types, including neurons, glial cells and the vasculature into a single culture. Grown ...

Remote-controlled CAR-T cells use venetoclax to disengage from tumors

Among the most promising tools of cancer therapy, engineered immune cells known as chimeric antigen-receptor (CAR) T cells have already transformed the treatment of blood cancers. Yet, despite their ...
EurekAlert!

Researchers uncover distinct tumor “neighborhoods”, with each cell subtype playing a specific role, in aggressive childhood brain cancer

New research published today in Nature finds that tumor cells within supratentorial ependymomas (SE) – an aggressive childhood brain cancer – cluster into distinct tumor cell populations. Much like a ...
eLife

Contractile peri-nuclear actomyosin network repositions peripheral and polar chromosomes to promote early kinetochore–microtubule interactions

This important study demonstrates that a peri-nuclear actomyosin network, present in some types of human cells, facilitates kinetochore-spindle attachment of chromosomes in unfavorable locations - ...