The bacterial translation initiation mechanism uses only three initiation factors: IF1, IF2 and IF3 (ref. 1). In recent years, their functional analogs have been identified in eukaryotic cells; namely ...
eIF2B is Regulated via the Phosphorylation of its Substrate, eIF2 eIF2[αP] acts as a potent competitive inhibitor of eIF2B, thereby blocking the regeneration of active eIF2.GTP and the initiation of ...
No therapies exist to prevent neuronal deficits in multiple sclerosis (MS), because the molecular mechanism responsible for the progressive neurodegeneration is unknown. We previously showed that axon ...
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