The precise role of the spliceosomal DEAD-box protein Prp28 in higher eukaryotes remains unclear. We show that stable tri-snRNP association during pre-catalytic spliceosomal B complex formation is ...

The Nature Index 2025 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...

Expanded C9ORF72 hexanucleotide repeats cause many cases of amyotrophic lateral sclerosis and frontotemporal dementia, but exactly how these expansions work their mischief remains a mystery.

Images of the model plant Arabidopsis thaliana. In the plant on the right, the activity of the protein-RNA complex "U1 snRNP" was artificially reduced. The plants are 21 days old. Plants have a ...

Scientists have created a model to study the role of RNA splicing defects in Alzheimer's disease, revealing degeneration and toxicity caused by neuron hyperexcitability. Researchers have puzzled over ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

In multicellular organisms, the earliest products of transcription, called pre-mRNAs, undergo a molecular makeover before shipping out to the cytoplasm, where the modified mRNAs spell out the recipe ...

(Memphis, Tenn.—October 13, 2022) Researchers have puzzled over the neurodegenerative disorder Alzheimer’s disease for decades, but treatments to stop or reverse the disease’s effects on the brain ...