The cell cycle uses ubiquitin-mediated proteolysis to ensure that the two daughter cells inherit an identical complement of chromosomes, and coordinate mitosis with cytokinesis. Specific mitotic ...
The anaphase promoting complex/cyclosome (APC/C) is crucial to the control of cell division (for a review, see ref. 1). It is a multi-subunit ubiquitin ligase that, at defined points during mitosis, ...
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