In vitro data demonstratedself-complementary AAV9 (scAAV9) enabled ~30-fold higher MeCP2 protein expression compared to single-stranded AAV9 ...

Researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital (NRI) have identified and characterized two regions of DNA required ...

Rett syndrome is a rare devastating neurological disorder that primarily affects young girls and manifests as an impaired ability to walk and talk, along with characteristic 'hand-wringing' movements, ...

A team of researchers has developed a strategy that allows them to identify potential treatments that would restore altered levels of MeCP2. Having twice the normal amount of the protein MeCP2, a ...

MeCP2 is a methyl DNA–binding transcriptional regulator that contributes to the development and function of CNS synapses; however, the requirement for MeCP2 in stimulus-regulated behavioral plasticity ...

This release is available in Spanish. A paper published online today in Molecular Cell proposes that Methyl CpG binding protein 2 (MeCP2) impacts the entire genome in neurons, rather than acting as a ...

Only 300 people in the world have been diagnosed with a deadly genetic condition called MeCP2 duplication syndrome. MeCP2 duplication is a cureless neurological condition that typically affects males ...

The methyl CpG binding protein 2 gene (MECP2) produces a protein of the same name, the level of which is critical for normal brain function. Mutations leading to protein under-expression cause Rett ...

The MECP2 Duplication Syndrome is reversible, say researchers. Importantly their study paves the way for treating duplication patients with an antisense oligonucleotide strategy. The methyl CpG ...

A paper published online today in Science provides evidence that the Methyl-CpG-Binding Protein 2 (MeCP2) is required throughout life to maintain healthy brain function. The findings are reported from ...

The idea that natural variants of a single gene could substantially influence brain structure might blow your mind. But a study in this week’s PNAS Early Edition suggests just that. A research team ...