The difference between mental health and mental illness can turn on changes in brain cells and their connections that are almost incomprehensibly tiny, at least in physical terms. This irony is ...

Drugs that act on NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, are key for treating neuropsychiatric disorders. These drugs were ...

It remains difficult to distinguish anti-NMDA receptor encephalitis from a primary psychiatric disorder, but recent studies have identified clinical features and proposed screening criteria that could ...

For all glutamate-gated channels, agonist-binding in the cleft formed by two dynamic lobes, D1 and D2, of ligand-binding domains (LBDs) is the event that energizes resting receptors to either open or ...

Gainesville, FL - Temporal summation of repeated pain stimuli, also known as "windup" pain, is mediated by N-methyl-D-aspartate (NMDA) receptors, and this pathway has long been suspected of ...

A new study suggests a potential molecular strategy for treating fragile X syndrome, an inherited neurodevelopmental disorder that causes autism spectrum disorder and intellectual disability. This ...

Structural biologists have obtained important scientific results likely to advance efforts to develop new drugs targeting NMDA receptors in the brain. Structural biologists at Cold Spring Harbor ...

STOCKTON, Calif. (KGO) -- A writer's inspiration can take many forms. For Joy Van, it happened while her son was hospitalized with a rare autoimmune disease. "I was sitting in the hospital with him ...

An investigational N-methyl-D-aspartate (NMDA)-receptor antagonist was effective at treating major depressive disorder in the phase III GEMINI trial. The 1:1 randomized controlled study of 327 adults ...

Allergan has acquired an investigational NMDA receptor modulator discovered by Aptinyx, exercising its option under an ongoing collaboration, and plans to pair it with its rapastinel depression ...