Nature

Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes

For many years, the t(15;17) has been the karyotypic marker of Acute Promyelocytic Leukemia (APL) (Rowley et al., 1977). The discovery of variant translocations, t(11;17)(q23;q21), t(11;17)(q13;q21), ...
Nature

Efficacy of gemtuzumab ozogamicin on ATRA- and arsenic-resistant acute promyelocytic leukemia (APL) cells

Acute promyelocytic leukemia (APL) cells express a considerable level of CD33, which is a target of gemtuzumab ozogamicin (GO), and a significantly lower level of P-glycoprotein (P-gp). In this study, ...