Inactivation of the tumour-suppressor protein p53 is a critical event in the pathogenesis of most cancers. 23 Loss of p53 function, for instance, has been linked to genomic instability, insensitivity ...

Measurement of genetic instability, a hallmark feature of solid tumours that is implicated in both initiation and progression of cancers, may serve as a valuable molecular marker of prognosis. Thyroid ...