A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a ...

Aided by two molecular control factors, the spliceosome rejects pre-mRNA that could be incorrectly spliced. While GPATCH1 detects the defective pre-mRNA, DHX35 removes it from the spliceosome, which ...

RNA technology is regarded as one of the newest frontiers in medicine, but in fact a primordial innovator got there way ...

Human genes that encode proteins often contain non-coding segments known as introns. Removing introns is crucial for the proper expression of genetic information. Understanding how our cells ...

Vigeneron GmbH has received IND approval from the FDA for VG-801, a novel mRNA trans-splicing gene therapy to treat Stargardt disease and other retinal dystrophies associated with mutations in the ...