Psilocybin neurologically weakens the brain circuits that keep you stuck in the same thoughts, and we can now see exactly how.In December 2025, the Kwan lab at Cornell published a study in Cell that mapped, for the first time, how the brain rewires post-psilocybin.You might recognize the Kwan lab. In 2021, they were the first to show that psilocybin grows new dendritic spines in the frontal cortex within 24 hours of a single dose. That study proved psilocybin physically changes brain structure.T

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